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Gadget Lab has seen a Windows 8 tablet in action, and the experience opened our eyes to just how useful -- and, yes, even fun -- a Windows 8 tablet might be. But will Windows 8 tablets actually be successful? We give you four reasons that say, yes, Windows 8 tablets might be a big surprise.
Eleven independent analysts forecast an average sales figure of 13.6 million light vehicles in 2012. The prediction would be an increase of 6-7% over this year depending on how 2011 wraps up. The spike in auto sales is attributed to rising employment, increasing credit availability, new products and aging vehicles currently driven by Americans. If, and that?s a big IF, consumers meet these expectations, that will be great news for shareholders of General Motors (NYSE:GM), Ford (NYSE:F), Toyota Motors (NYSE:TM), and Honda Motor Company (NYSE:HMC).
Don?t Miss: Iran Threatens to Block Oil Flow Through Vital Strait of Hormuz in Response to U.S. Sanctions.
Though the most conservative estimate of 13 million by Wells Fargo (NYSE:WFC) is a full million less than the loftiest of 14 million by Morgan Stanley (NYSE:MS), the spread is still narrower than the 1.5 million difference in 2011 predictions. Analysts predict just as much economic bad news in 2012, but believe consumers are less skittish than they were three years ago when the recession began.
Automotive News quoted Alec Gutierrez, Senior Market Analyst for Kelley Blue Book, who said, ?The Dow fell 1,500 points ? and car sales stayed smooth and consistent. The American consumer has seen so much gone wrong. If they have to buy a car, they will.?
While a European recession is possible in 2012, it could possibly be outweighed by an American economic surge. Jeff Schuster, a forecaster for the Americas for LMC Automotive, says that the more telling factors will be pent-up demand, a growing inventory, and credit availability.? The average age of vehicles on the road is currently 10.7 years, up from 8 or 9 over the past decade according to Tom Kontos, Executive Vice President of Customer Strategies and Analytics for auction house ADESA. ?Americans have gone without for a very long time.? ?I need a car? is the biggest reason for optimism,? Kontos said per Automotive News.
Investing Insights: Oil ETFs: The Top 10 Exchange Traded Funds for Your Oil Investing List.
To contact the reporter on this story: Ashley Cloninger at staff.writers@wallstcheatsheet.com
To contact the editor responsible for this story: Damien Hoffman at editors@wallstcheatsheet.com
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Lots of US cities claim they're the best place to do a startup. So where are entrepreneurs actually starting companies these days? TechCrunch reader Yuval Baror took a look at CrunchBase to try to answer the question. His most surprising result is that New York has been getting quite a few more startups than other cities outside of Silicon Valley. There's actually something to all the hype being cooked up by New York media companies and politicians, apparently.?Of course, the San Francisco-Silicon Valley region is still the clear leader.
Tom Lowe has been restlessly working on Timescapes for more than two years now. You probably already saw the first trailer of this breathtaking ultra-HD silent film. This is the newest material. A must watch. More »
STILLWATER, Okla. ? Thousands of fans stormed the field and tore down goalposts after Oklahoma State's 44-10 victory over archrival Oklahoma, leaving at least 13 people injured, including two in critical condition, medical authorities said early Sunday.
Michael Authement, who heads the command post at emergency medical provider LifeNet EMS, told The Associated Press that a throng so big took to the field as the game ended that some fans were trampled and one person fell at least 15 feet onto concrete during a wild celebration by Oklahoma State fans.
No. 13 Oklahoma State routed the Sooners on Saturday night to win the Big 12 championship and make its case to play for the BCS national title. The Cowboys (11-1, 8-1 Big 12) snapped an eight-game losing streak in the rivalry and won their first outright conference title since 1948 in the three-team Missouri Valley.
"They won the game and stormed the field and ripped down the goalposts, and some were jumping off the stands and hit the field and others got trampled. It was a nasty deal," Authement said.
He said the crowd was so big it took police at least 45 minutes to clear fans from the field at the university's Boone Pickens Stadium, which has a capacity of more than 60,000 people, according to the school's website.
"There were thousands of people. Thousands of people stormed the field. You couldn't move there were so many people," he added.
AP photographs showed fans climbing atop the yellow goalposts and tearing them apart amid a crush of people on the field. Scores of hands stretched out to pull down the goalposts during the celebration.
Authement said nine ambulances, including six from LifeNet, rushed 11 of the injured away and the two with critical injuries were flown to Oklahoma City hospitals. He said he knew of leg fractures but didn't have any details on the extent of the injuries, though two of the 13 had minor injuries and were treated at the scene and released.
A spokeswoman for Integris Baptist Medical Center in Oklahoma City wouldn't release details Sunday morning about patients being treated there. Phone messages and emails sent to several university and athletic department spokespeople weren't immediately returned.
Lesser injuries included broken ankles, ankle sprains and back sprains, said Shyla Eggers, public relations director for Stillwater Medical Center. She told AP that her hospital received six of the injured in ambulances and two in private vehicles, and at least two of them have been admitted and would undergo surgery on broken ankles.
"Our staff that was on hand took care of it. They were just very busy," Eggers said. "Game day is always busy."
She had no immediate details on the more serious injuries.
An Oklahoma State University police central dispatcher said she had no immediate details to release when contacted by AP, and the public information officer did not immediately return messages seeking comment. Stillwater police said they had a handful of officers at the game, and Oklahoma highway patrol had no immediate comment.
Authement said fans began storming the field with about 20 seconds left in the game. He said he had reports of people falling and being trampled in the surge.
"This was way worse than the earthquake," Authement said, referring to the magnitude-5.6 quake that hit central Oklahoma and the same stadium as fans were leaving a game Nov. 5. It was the strongest earthquake in the state's history.
During Saturday's game, the marching bands from both universities performed Amazing Grace to honor Oklahoma State head women's basketball coach Kurt Budke and his assistant coach, Miranda Serna, who were killed in a plane crash last month during a recruiting trip. The pilot, Olin Branstetter, and his wife, Paula, who were also killed, also were honored.
BGI reports study results on frequent mutation of genes encoding UMPP components in kidney cancerPublic release date: 4-Dec-2011 [ | E-mail | Share ]
Contact: Jia Liu liujia@genomics.cn BGI Shenzhen
Study published online today in Nature Genetics
December 4th, 2011, Cambridge, MA and Shenzhen, China BGI, the world's largest genomics organization, announced that a study on frequent mutation of genes encoding ubiquitin-mediated proteolysis pathway (UMPP) components in clear cell renal cell carcinoma (ccRCC) is published online today in Nature Genetics. In addition to BGI, co-leaders of the study included Peking University Shenzhen Hospital, Shenzhen Second People's Hospital, among others. The study reveals that alteration of UMPP may contribute to ccRCC by activation of the hypoxia regulatory network, providing new clues to trace the key molecular mechanisms and pathways that underlie the tumorigenesis and progression of ccRCC.
Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive type of kidney cancer, with 102,000 deaths worldwide each year. It is characterized by high metastatic potential and poor prognosis. Up to 40% of patients have disease recurrence after nephrectomy. In this study, the research team specifically looked at alterations in ubiquitin-mediated proteolysis pathway and studied its potential impacts linked to ccRCC tumorigenesis. The UMPP has been reported to be associated with many diseases including cancer and plays a critical role in the protein metabolism as a major pathway for protein degradation in cells.
"Adding to the previous research effort of transitional cell carcinoma in bladder cancer published in Nature Genetics earlier this year, we and our partners continued our study of strongly aggressive ccRCC tumors to identify the mutated genes associated with the process of tumorigenesis," said Guangwu Guo, one of the co-leading authors of the study and PI of this project at BGI. "The new discoveries in this study led us to a remarkable step in our understanding of the genetic landscape of ccRCCs and toward potential treatment against this aggressive tumor."
To gain a deep insight into the genetic basis of ccRCC, researchers analyzed ten primary tumors with matched morphologically normal renal tissues utilizing the whole exome sequencing approach on BGI's sequencing platform. The mutation prevalence was estimated by screen of ~1,100 genes with somatic mutations or that have been causally implicated in cancers in 88 additional ccRCCs for prevalence screen.
There were 23 significantly mutated genes identified in the 98 ccRCCs, including the five well-known renal cancer genes such as VHL and TP53, and genes involved in chromatin modification such as PBRM1, JARID1C and SETD2. "We have identified 12 genes which were previously unknown to be involved in ccRCC, including two tumor suppressor genes, BAP1 and TSC1. Integration of previous studies and our findings suggest that some of the genes may play important roles in ccRCC genesis," said Guo.
In addition to the attempt to identify all mutated genes associated with ccRCC, researchers also focused on specific genes, pathways and mechanisms that potentially play a key role in ccRCC tumorgenesis and warrant exploration as potential targets for treatments. One of the targets was mutations in VHL gene that were commonly suggested to be involved in ccRCC genesis in many previous genetic studies with reported prevalence ranging between 50% and 80%. Interestingly, researchers have found a much lower prevalence of 27% in this study. VHL promoter hypermethylation was only found in 6% of the tumors relative to their matched normal samples, also suggesting a lower prevalence of epigenetic VHL alternation, according to the researchers.
Although the alteration of VHL gene is widely known for its association with kidney cancer, researchers also revealed the frequent mutation of UMPP linked to ccRCC in this study and have sequenced all 135 genes in UMPP in the prevalence screen. A significantly high mutation frequency of UMPP was found in the 98 carcinoma samples. The pathway analysis suggested that alternation of UMPP could potentially play an important role in ccRCC tumorigenesis, and it may contribute by activating the hypoxia regulatory network.
"This study has enhanced our knowledge and laid an important foundation for future research of ccRCC. The new discovery on the potential contribution of UMPP to ccRCC justifies more comprehensive investigation of this pathway, including proteomics research of the protein network to fully elucidate its role in ccRCC genesis," said Professor Jun Wang, Executive Director of BGI.
###
About BGI
BGI was founded in Beijing, China, in 1999 with the mission to become a premier scientific partner for the global research community. The goal of BGI is to make leading-edge genomic science highly accessible, which it achieves through its investment in infrastructure, leveraging the best available technology, economies of scale, and expert bioinformatics resources. BGI, and its affiliates, BGI Americas, headquartered in Cambridge, MA, and BGI Europe, headquartered in Copenhagen, Denmark, have established partnerships and collaborations with leading academic and government research institutions as well as global biotechnology and pharmaceutical companies, supporting a variety of disease, agricultural, environmental, and related applications.
BGI has a proven track record of excellence, delivering results with high efficiency and accuracy for innovative, high-profile research: research that has generated over 170 publications in top-tier journals such as Nature and Science. BGI's many accomplishments include: sequencing one percent of the human genome for the International Human Genome Project, contributing 10 percent to the International Human HapMap Project, carrying out research to combat SARS and German deadly E. coli, playing a key role in the Sino-British Chicken Genome Project, and completing the sequence of the rice genome, the silkworm genome, the first Asian diploid genome, the potato genome, and, more recently, have sequenced the human Gut Metagenome, and a significant proportion of the genomes for the1000 Genomes Project. For more information about BGI, please visit www.genomics.cn or www.bgiamericas.com.
Contact Information:
Guangwu Guo, Ph.D.
Group Leader of Cancer Genome Analysis,
BGI
guogw@genomics.cn
www.genomics.cn
Joyce Peng, Ph.D.
Marketing Director
BGI Americas
626-222-5584
joyce.peng@bgiamericas.com
www.bgiamericas.com
Bicheng Yang, Ph.D.
Public Communication Officer
BGI
+86-755-82639701
yangbicheng@genomics.cn
www.genomics.cn
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
BGI reports study results on frequent mutation of genes encoding UMPP components in kidney cancerPublic release date: 4-Dec-2011 [ | E-mail | Share ]
Contact: Jia Liu liujia@genomics.cn BGI Shenzhen
Study published online today in Nature Genetics
December 4th, 2011, Cambridge, MA and Shenzhen, China BGI, the world's largest genomics organization, announced that a study on frequent mutation of genes encoding ubiquitin-mediated proteolysis pathway (UMPP) components in clear cell renal cell carcinoma (ccRCC) is published online today in Nature Genetics. In addition to BGI, co-leaders of the study included Peking University Shenzhen Hospital, Shenzhen Second People's Hospital, among others. The study reveals that alteration of UMPP may contribute to ccRCC by activation of the hypoxia regulatory network, providing new clues to trace the key molecular mechanisms and pathways that underlie the tumorigenesis and progression of ccRCC.
Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive type of kidney cancer, with 102,000 deaths worldwide each year. It is characterized by high metastatic potential and poor prognosis. Up to 40% of patients have disease recurrence after nephrectomy. In this study, the research team specifically looked at alterations in ubiquitin-mediated proteolysis pathway and studied its potential impacts linked to ccRCC tumorigenesis. The UMPP has been reported to be associated with many diseases including cancer and plays a critical role in the protein metabolism as a major pathway for protein degradation in cells.
"Adding to the previous research effort of transitional cell carcinoma in bladder cancer published in Nature Genetics earlier this year, we and our partners continued our study of strongly aggressive ccRCC tumors to identify the mutated genes associated with the process of tumorigenesis," said Guangwu Guo, one of the co-leading authors of the study and PI of this project at BGI. "The new discoveries in this study led us to a remarkable step in our understanding of the genetic landscape of ccRCCs and toward potential treatment against this aggressive tumor."
To gain a deep insight into the genetic basis of ccRCC, researchers analyzed ten primary tumors with matched morphologically normal renal tissues utilizing the whole exome sequencing approach on BGI's sequencing platform. The mutation prevalence was estimated by screen of ~1,100 genes with somatic mutations or that have been causally implicated in cancers in 88 additional ccRCCs for prevalence screen.
There were 23 significantly mutated genes identified in the 98 ccRCCs, including the five well-known renal cancer genes such as VHL and TP53, and genes involved in chromatin modification such as PBRM1, JARID1C and SETD2. "We have identified 12 genes which were previously unknown to be involved in ccRCC, including two tumor suppressor genes, BAP1 and TSC1. Integration of previous studies and our findings suggest that some of the genes may play important roles in ccRCC genesis," said Guo.
In addition to the attempt to identify all mutated genes associated with ccRCC, researchers also focused on specific genes, pathways and mechanisms that potentially play a key role in ccRCC tumorgenesis and warrant exploration as potential targets for treatments. One of the targets was mutations in VHL gene that were commonly suggested to be involved in ccRCC genesis in many previous genetic studies with reported prevalence ranging between 50% and 80%. Interestingly, researchers have found a much lower prevalence of 27% in this study. VHL promoter hypermethylation was only found in 6% of the tumors relative to their matched normal samples, also suggesting a lower prevalence of epigenetic VHL alternation, according to the researchers.
Although the alteration of VHL gene is widely known for its association with kidney cancer, researchers also revealed the frequent mutation of UMPP linked to ccRCC in this study and have sequenced all 135 genes in UMPP in the prevalence screen. A significantly high mutation frequency of UMPP was found in the 98 carcinoma samples. The pathway analysis suggested that alternation of UMPP could potentially play an important role in ccRCC tumorigenesis, and it may contribute by activating the hypoxia regulatory network.
"This study has enhanced our knowledge and laid an important foundation for future research of ccRCC. The new discovery on the potential contribution of UMPP to ccRCC justifies more comprehensive investigation of this pathway, including proteomics research of the protein network to fully elucidate its role in ccRCC genesis," said Professor Jun Wang, Executive Director of BGI.
###
About BGI
BGI was founded in Beijing, China, in 1999 with the mission to become a premier scientific partner for the global research community. The goal of BGI is to make leading-edge genomic science highly accessible, which it achieves through its investment in infrastructure, leveraging the best available technology, economies of scale, and expert bioinformatics resources. BGI, and its affiliates, BGI Americas, headquartered in Cambridge, MA, and BGI Europe, headquartered in Copenhagen, Denmark, have established partnerships and collaborations with leading academic and government research institutions as well as global biotechnology and pharmaceutical companies, supporting a variety of disease, agricultural, environmental, and related applications.
BGI has a proven track record of excellence, delivering results with high efficiency and accuracy for innovative, high-profile research: research that has generated over 170 publications in top-tier journals such as Nature and Science. BGI's many accomplishments include: sequencing one percent of the human genome for the International Human Genome Project, contributing 10 percent to the International Human HapMap Project, carrying out research to combat SARS and German deadly E. coli, playing a key role in the Sino-British Chicken Genome Project, and completing the sequence of the rice genome, the silkworm genome, the first Asian diploid genome, the potato genome, and, more recently, have sequenced the human Gut Metagenome, and a significant proportion of the genomes for the1000 Genomes Project. For more information about BGI, please visit www.genomics.cn or www.bgiamericas.com.
Contact Information:
Guangwu Guo, Ph.D.
Group Leader of Cancer Genome Analysis,
BGI
guogw@genomics.cn
www.genomics.cn
Joyce Peng, Ph.D.
Marketing Director
BGI Americas
626-222-5584
joyce.peng@bgiamericas.com
www.bgiamericas.com
Bicheng Yang, Ph.D.
Public Communication Officer
BGI
+86-755-82639701
yangbicheng@genomics.cn
www.genomics.cn
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
LIMA (Reuters) ? Peruvian President Ollanta Humala declared a state of emergency late on Sunday to quell protests against Newmont Mining's $4.8 billion Conga mine project that have hobbled the region of Cajamarca for 11 days.
Humala, in a nationwide address, called leaders of the environmental protest intransigent and said the ruling would give security forces added power to ensure that roads, schools and hospitals could reopen after having been shuttered for days by rallies and marches against the proposed mine.
It was the first time in Humala's young presidency that he has used extraordinary powers to defuse a social conflict over mining in Peru, where some 200 disputes nationwide threaten to delay billions of dollars in planned mining and oil projects.
"Every possible means has been exhausted to establish dialogue and resolve the conflict democratically, but the intransigence of local and regional leaders has been exposed - not even the most basic agreements could be reached to ensure social peace and the reestablishment of public services," he said.
Humala campaigned on promises to steer more social spending to rural towns to help calm social conflicts over natural resources while assuring companies they could move ahead with new mining and oil projects.
He has urged mediation to solve the disputes, but nearly a week ago the government was forced to ask Newmont to temporarily halt work on the Conga mine after the protests turned violent. Since then protesters have continued to march and demanded the government permanently cancel the project.
Prime Minister Salomon Lerner negotiated on Sunday for hours with leaders of the protest, who say the mine will hurt water supplies and caused pollution.
But Lerner failed to reach an accord with protesters, prompting Humala to invoke a state of emergency - a tool that his predecessor, former President Alan Garcia, frequently used to quash social protests.
(Reporting by Teresa Cespedes and Terry Wade; editing by Philip Barbara)
In this July 6, 2011 photo, a full scale rendition of the house in the animated movie, "Up," located a in Herriman, Utah, will be part of this year's Parade of Homes. The house has been sold to a family who are self-described Disney and Pixar fanatics. Clinton and Lynette Hamblin of Petaluma, Calif., are buying the home in Herriman, Utah, for $400,000. The Hamblins say they were searching for a home in California that was similar to the colorful cottage seen in the movie when they heard about the Disney-approved "Up" house in Utah. (AP Photo/The Salt Lake Tribune, Paul Fraughton)
In this July 6, 2011 photo, a full scale rendition of the house in the animated movie, "Up," located a in Herriman, Utah, will be part of this year's Parade of Homes. The house has been sold to a family who are self-described Disney and Pixar fanatics. Clinton and Lynette Hamblin of Petaluma, Calif., are buying the home in Herriman, Utah, for $400,000. The Hamblins say they were searching for a home in California that was similar to the colorful cottage seen in the movie when they heard about the Disney-approved "Up" house in Utah. (AP Photo/The Salt Lake Tribune, Paul Fraughton)
FILE - This July 6, 2011 file photo shows a full scale rendition of the house in the animated movie "Up" lin Herriman, Utah. This highly detailed recreation of the house from the Academy Award-winning movie "Up" has become a curious visitor attraction in this suburban development south of Salt Lake City. It's now been sold by the builder to a couple who loved the movie as much as he did. (AP Photo/The Salt Lake Tribune, Paul Fraughton, File)
This Oct. 13, 2011, photo shows details inside a house modeled after the home from the Pixar animated film "Up,"in Herriman, Utah. The home has been sold to a family who are self-described Disney and Pixar fanatics. Clinton and Lynette Hamblin of Petaluma, Calif., are buying the home for $400,000. (AP Photo/The Salt Lake Tribune, Trent Nelson)
This Oct. 13, 2011, photo shows details in the front room inside a house modeled after the home from the Pixar animated film "Up,"in Herriman, Utah. The home has been sold to a family who are self-described Disney and Pixar fanatics. Clinton and Lynette Hamblin of Petaluma, Calif., are buying the home for $400,000. (AP Photo/The Salt Lake Tribune, Trent Nelson)
This Oct. 13, 2011, photo shows a room inside a house modeled after the home from the Pixar animated film "Up,"in Herriman, Utah. The home has been sold to a family who are self-described Disney and Pixar fanatics. Clinton and Lynette Hamblin of Petaluma, Calif., are buying the home for $400,000. (AP Photo/The Salt Lake Tribune, Trent Nelson)
SALT LAKE CITY (AP) ? Two self-described Disney "fanatics" have purchased a house in Utah modeled after the colorful home featured in the animated movie "Up."
Discovering the house in the Salt Lake City suburb of Herriman, Utah, was a dream come true for Clinton and Lynette Hamblin of Petaluma, Calif. The couple had been looking for a house with some of the same flourishes as the one in the movie, such as a multi-colored exterior or a blue kitchen with retro appliances.
They initially looked in California until they saw news reports about the house in Utah that included every possible detail from the movie and was even officially recognized as the "Up" house by Disney. Even more surprising was the $400,000 price tag, which was less than homes they looked at in California.
For them, however, the real attraction to the house was it underscored the overriding theme of the movie.
"We just love the message of the movie ? adventure is out there," Lynette Hamblin told The Salt Lake Tribune.
The house is modeled on its appearance early in the movie, when Carl and Ellie Frederickson are flush with the optimism of newlyweds. That was before infertility undid their hopes for a family and Ellie's death left Carl a curmudgeonly recluse who refuses to succumb to developers and sell his house.
Homebuilder Adam Bangerter told The Associated Press earlier this year that he and his brothers ? who collectively own Bangerter Homes ? wanted to replicate the house because it's iconic and plays an important role in the movie.
"It illustrates what homeownership really is, and it's not an investment. It's part of the American dream to have a house to care for, to improve and to make part of your family," Bangerter said during a tour of the house.
Herriman City spokeswoman Nicole Martin said about 45,000 people have visited the home for tours, and will continue to do so through the month of December. City leaders even recently passed a resolution honoring the house for its economic impact.
The Hamblins plan to move into the home after closing Jan. 4, which happens to be Lynette Hamblin's birthday.
AAA??Dec. 2, 2011?4:55 PM ET Lindsey Vonn wins World Cup downhill AP
Lindsey Vonn, of the United States, races down the course during the women's World Cup downhill ski competition in Lake Louise, Alberta, Friday, Dec. 2, 2011. (AP Photo/The Canadian Press, Frank Gunn)
Lindsey Vonn, of the United States, races down the course during the women's World Cup downhill ski competition in Lake Louise, Alberta, Friday, Dec. 2, 2011. (AP Photo/The Canadian Press, Frank Gunn)
USA's Lindsey Vonn races down the course during a training run at the women's World Cup downhill ski competition in Lake Louise, Alberta, Thursday, Dec. 1, 2011. (AP Photo/The Canadian Press, Frank Gunn)
Lindsey Vonn, of the United States, reacts in the finish area after her run in the women's World Cup downhill ski competition in Lake Louise, Alberta, Friday, Dec. 2, 2011. Vonn won the race. (AP Photo/The Canadian Press, Jeff McIntosh)
Lindsey Vonn, of the United States, reacts in the finish area after her run in the women's World Cup downhill ski competition in Lake Louise, Alberta, Friday, Dec. 2, 2011. Vonn won the race. (AP Photo/The Canadian Press, Jeff McIntosh)
Winner Lindsey Vonn, center, of the United States, is joined by second place finisher Tina Weirather, left, of Liechtenstein, and third place finisher Dominique Gisin, of Switzerland, as they celebrate on the podium at the women's World Cup downhill ski competition in Lake Louise, Alberta, Friday, Dec. 2, 2011. (AP Photo/The Canadian Press, /Jeff McIntosh
LAKE LOUISE, Alberta (AP) ? Lindsey Vonn won the World Cup women's downhill Friday at Lake Louise for her ninth career victory at the resort.
The American star finished in 1 minute, 53.19 seconds to beat Liechtenstein's Tina Weirather by 1.95 seconds. Switzerland's Dominique Gisin was third in 1:55.29.
Vonn has won at least one race at Lake Louise in eight straight years.
Another downhill is scheduled for Saturday and a super-G is set for Sunday.
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NAYPYITAW (Reuters) ? Myanmar's new capital, Naypyitaw, translates as "Abode of Kings," fitting for Secretary of State Hillary Clinton to begin historic talks that could restore some luster to one of the world's most reclusive states.
But as she arrived on Wednesday to become the first U.S. secretary of state to visit Myanmar in more than 50 years, there were no crowds, no festivities, no flags and seemingly few preparations aside from some policemen outside the hotel compound where she will stay and on nearby roads.
In striking contrast, a large billboard had been strung up at a nearby hotel, welcoming the prime minister of Belarus, who is also due to visit in coming days.
Some workers were sweeping the wide but mostly deserted boulevards of the sprawling city built from scratch just five years ago, where Myanmar's leaders and powerful retired generals have isolated themselves, some 320 km (200 miles) from the largest city and former capital, Yangon.
At the airport, she was greeted by a small delegation led by Myanmar's foreign minister.
Naypyitaw is a maze of ministry buildings, government mansions, civil servants' quarters and presidential palaces complete with grand Roman-style pillars -- all rising from dusty, arid scrubland. At its heart are parliament's 31 buildings, with pagoda-style roofs.
Bestowed with manicured lawns and forbidding stone walls, it bears no resemblance to the rest of Myanmar, one of Asia's poorest countries, or even to nearby villages, where many people live in thatched wooden huts.
Attractions include half a dozen resorts and golf courses, drinkable tap water, a Western-style shopping mall, a zoo, a grand "water fountain garden," lavish mansions and 24-hour electricity in a nation beset by chronic power outages.
A laborer at a construction site next to parliament said he had no idea who was visiting.
"All I know is someone important is coming but I don't know who," said the worker, Ye Pun Naing. Told that it was Clinton, he shrugged his shoulders and said that meant nothing to him.
That's not too surprising.
Myanmar has only just begun to emerge from an extraordinary half-century of isolation. The past few months have seen the most dramatic changes in the former British colony since the military took power in a 1962 coup when it was known as Burma.
A string of reforms, breathtaking by Myanmar's standards, have been introduced by former generals who swapped fatigues for civilian clothes in March when a new parliament opened following last year's elections, the first in two decades.
While in South Korea earlier on Wednesday, Clinton expressed cautious optimism that Myanmar's tentative democratic reforms could develop into a movement for change to the benefit of the people.
PUZZLINGLY WIDE ROADS
Unarmed policemen were seen in pairs or small along some roads, along with occasional trucks carrying riot police armed with shields, baton and guns.
"A number of foreign dignitaries are due to arrive here in a day or two," said Ma Nyein, 26, as she tended roadside plants. She said she had never heard of Clinton, although she knew who U.S. President Barack Obama was.
Much of Naypyitaw was built by workers like Ma Nyein, toiling in searing heat with basic equipment. When Reuters journalists visited early last year, women were hauling stacks of bricks balanced upon their head and men cleared land with wooden-handled scythes. Ox carts transported wood.
Diplomatic sources say the construction of Naypyitaw would have cost billions of dollars, drawing criticism from aid groups over the priorities of a country where a third of the population lives in poverty and where infrastructure is in tatters due to trade-crippling sanctions and mismanagement.
The city's rise reflects the riches reaped by its rulers as Southeast Asia and China tap its natural resources, from timber and natural gas to precious gems, despite the Western sanctions imposed in response to rights abuses.
It may have amenities but there's no lively city centre thronged with people, even five years after the government moved nearly all its workers there. Officials put its population at about 1 million, including outlying townships.
Its roads are puzzlingly wide, including one 20-lane boulevard, but they are largely empty. Civilian cars are rare. The city centre, a roundabout where five roads meet, is populated mostly by palm trees and potted flowers.
One person the former ruling junta were happy to leave in Yangon was opposition leader Aung San Suu Kyi, a Nobel laureate freed from years of detention last year.
But Suu Kyi has since visited several times and could even enter parliament when her political party contests by-elections expected early next year.
(Additional reporting by Aung Hla Tun; Writing by Jason Szep; Editing by Robert Birsel)
BATON ROUGE, La. (AP) ? A Baton Rouge rapper known as "Lil Boosie" has been sentenced to eight years in prison following his guilty plea to drug charges.
The 29-year-old rapper's real name is Torrence Hatch. He pleaded guilty Tuesday to conspiring to smuggle codeine, marijuana and ecstasy into two state prisons. They were the Louisiana State Penitentiary at Angola and Dixon Correctional Institute in Jackson, La.
Assistant District Attorney Dana Cummings says Hatch was serving a prison term for a separate conviction for marijuana possession when he smuggled the drugs with help from a prison guard.
State District Judge Mike Erwin in Baton Rouge sentenced him to the new prison term.
Hatch also faces a first-degree murder charge in the 2009 death of Terry Boyd. The trial is scheduled to start April 30.
Maksim Gelman was arrested in February after the spree that included stabbing his stepfather and acquaintances to death, running over a pedestrian, carjacking and other violence.
By Colleen Long, NBCNewYork.com
A man accused of killing four people and wounding four others in a 28-hour rampage across Brooklyn and Manhattan earlier this year suddenly pleaded guilty Wednesday to murder and other charges.
Maksim Gelman was arrested in February after the spree that included stabbing his stepfather and acquaintances to death, running over a pedestrian, carjacking and other violence. Gelman had previously pleaded not guilty to the murder charges brought by Brooklyn prosecutors. At the time, he was under medical supervision, and his attorney, Edward Friedman, described his mental state as "fragile."
But, given the evidence in the case and a doctor's opinion that Gelman couldn't argue he was not guilty by reason of insanity, Gelman decided he wanted to get out of his holding cell ? and start serving his time in a permanent facility, his lawyer said.
Read the original story on NBCNewYork.com
The 24-year-old Ukraine-born man answered "yes" when asked if he understood what it meant to change his plea. Wearing a baggy orange jumpsuit, his hands cuffed behind his back and his hair closely cropped, Gelman answered the judge at a clip, saying "yes," ''yep" and "It sure is," as the 13-count indictment was read aloud.
The courtroom was empty except for reporters and the boyfriend of one of the victims who cried silently in the second row. Earlier court hearings had been packed.
Gelman faces life in prison, but a sentencing date hasn't yet been set. Friedman has asked for another psychiatric evaluation to show Gelman needs treatment. The Brooklyn district attorney's office said it would seek life in prison. A sentencing hearing has been scheduled for Jan. 11.
"It's quite likely, almost guaranteed, that any sentence I give means you'd never be released from a penal institution while you are alive," Judge Vincent DelGiudice said.
Gelman said he understood. "Have a good one," he said to his lawyer after he was led away.
Gelman's deadly spree started with a family argument over whether he could use his mother's car, authorities said.
After stabbing to death his stepfather in the family's Brooklyn apartment, Gelman went to the home of a female acquaintance, Yelena Bulchenko, prosecutors said. Bulchenko's friends have said he was obsessed with the 20-year-old woman and imagined a romantic relationship with her.
Gelman killed Bulchenko's 56-year-old mother, then waited hours for the daughter to return and stabbed her 11 times, authorities said. He then left the Bulchenkos' home, rear-ended a car and stabbed its driver, they said. The driver survived.
Stealing the wounded man's car, Gelman drove off and plowed into a pedestrian who died from his injuries, police said. After abandoning the car, Gelman later hailed a livery cab and attacked its driver, then approached another car, attacked a man inside and seized the car, police said. Both men survived.
All those attacks happened in Brooklyn. Gelman was next spotted on a subway in Manhattan, where passengers recognized him from newspaper photographs and notified police, authorities said. He dashed across the tracks, switched trains and attacked a final passenger before he was grabbed by police who were in the subway car looking for him on the tracks. The Manhattan case is still pending.
Police later recovered a bloody knife, three straight razor blades, a paring knife and $932.
According to court documents filed by prosecutors, Gelman told a police officer, "I'll beat this. I'll go to a mental hospital for a few years, and I'll get out on the street again, you'll see."
When asked by police why the four victims had to die, Gelman said, "Because I said so," according to the documents.
Outside court, Bulchenko's boyfriend, Gerard Honig, said he was just happy that Gelman was guilty.
"I just want him to get as much time as he can, that's it," he said.
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Public release date: 4-Dec-2011
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